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| {{http://woldlab.caltech.edu/images/myf5-section.jpg|Myf5 Section|align=left,height=151,width=116}} A substantial biological challenge is to understand the regulation and execution of developmental decisions that lead from multipotential, undifferentiated precursor cells to their specialized differential products. In the Wold lab at the California Institute of Technology, we are interested in several interrelated aspects of this problem, and we also work to develop new methods for studying it. The particular cell lineage problem we study begins with the specification of mesoderm in early development and continues to the final differentiation of skeletal muscle or cardiac muscle in the fully developed animal. To study this process we use the mouse as our experimental system. Molecular-level analyses use cell culture model systems and transgenic mice. These projects include studies of in vitro and in vivo protein-DNA interactions and of factors that amplify or suppress expression activity. Computational approaches involve the development of algorithms for use in large-scale gene expression analysis and the construction of a simulator framework for regulation in muscle development. | {{https://woldlab.caltech.edu/images/myf5-section.jpg|Myf5 Section|height=151,width=116}} A substantial biological challenge is to understand the regulation and execution of developmental decisions that lead from multipotential, undifferentiated precursor cells to their specialized differential products. In the Wold lab at the California Institute of Technology, we are interested in several interrelated aspects of this problem, and we also work to develop new methods for studying it. The particular cell lineage problem we study begins with the specification of mesoderm in early development and continues to the final differentiation of skeletal muscle or cardiac muscle in the fully developed animal. To study this process we use the mouse as our experimental system. Molecular-level analyses use cell culture model systems and transgenic mice. These projects include studies of in vitro and in vivo protein-DNA interactions and of factors that amplify or suppress expression activity. Computational approaches involve the development of algorithms for use in large-scale gene expression analysis and the construction of a simulator framework for regulation in muscle development. |
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| == 2008Jul25 05:08:39 PM - Server Failure on July 17th == We had a major server failure and some website related data loss. We have been working hard to fix the situation and restore the website. Currently the website is backup, but not everything is completely setup. If you find a link is broken and need access to a file or something that is now missing, please contact Brandon King at kingb (a) caltech.edu and we will do our best to fix the problem as quickly as possible. |
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| == 2007May04 04:56:15 PM - New Website == As you can see, we have launched our new website using our own Python Django based content management system (Only took 5 days to write thanks to Django). Hope you enjoy it. |
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| The old website is still available at http://woldlab.caltech.edu/oldindex.shtml. | [[ WoldLabNews | Edit News ]] |
Welcome to the Wold Lab
A substantial biological challenge is to understand the regulation and execution of developmental decisions that lead from multipotential, undifferentiated precursor cells to their specialized differential products. In the Wold lab at the California Institute of Technology, we are interested in several interrelated aspects of this problem, and we also work to develop new methods for studying it. The particular cell lineage problem we study begins with the specification of mesoderm in early development and continues to the final differentiation of skeletal muscle or cardiac muscle in the fully developed animal. To study this process we use the mouse as our experimental system. Molecular-level analyses use cell culture model systems and transgenic mice. These projects include studies of in vitro and in vivo protein-DNA interactions and of factors that amplify or suppress expression activity. Computational approaches involve the development of algorithms for use in large-scale gene expression analysis and the construction of a simulator framework for regulation in muscle development.
News
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